Smarter mRNA Starts with Smarter Chemistry Unlock mRNA performance with post-transcriptional chemical modifications. Unlock Smarter mRNA Now
Technology

Unlocking the Chemical Space of mRNA Modifications

Enzymatic production of mRNA by in vitro transcription severely constrains the diversity of chemical modifications
that can be incorporated. Amptiv overcomes this bottleneck by adding chemical modifications after mRNA synthesis,
unlocking a new chemical space to tune mRNA stability, immunogenicity, and overall performance.

A New Dimension of mRNA Design

Amptiv’s core platform uses a post-transcriptional chemical modification system that bypasses the legacy constraints
of enzymatic mRNA production. Invented at Stanford, this system allows for the addition of a wide range of chemical
modifications to optimize mRNA performance. We integrate wet-lab synthesis, functional assays, and Al-guided optimization
to enable high- performing mRNA.

• Design mRNA for specific outcomes

Tune half-life, immunogenicity, and performance to match therapeutic goals

• Simple and scalable

Manufacture mRNA using standard IVT systems, then add Amptiv chemical mods to long mRNA with a simple aqueous reaction.

• Access novel mRNA designs

Add modifications to enhance translation, durability, immunogenicity, and expression.

• Flexible mods

Choose permanent or reversible modifications as appropriate for therapeutic goals.

Team

Jon Bell, CEO

Chief Executive Officer

Jon Armstrong, CSO

Chief Scientific Officer

Hannah Baumann, Scientist II

Scientist II

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